Cactus found in Mexico and southwestern Texas used worldwide as an entheogen and supplement to transcendence. Native North Americans have used peyote for spiritual purposes for more than 5,500 years. Mescaline, the primary psychoactive compound isolated from peyote, is a controlled substance in Canada, while possession and use of peyote plants is legal. Peyote is a Schedule I controlled substance in the US, banned except for members of the Native American Church under the American Indian Religious Freedom Act.

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