Author of Marijuana Rx: The Patients Fight for Medical Pot, Robert Randall (1948–2001), who founded the Alliance for Cannabis Therapeutics, was the first person to successfully use a medical necessity defense when he was charged with illegal possession of cannabis to treat his glaucoma. Randall v. United States led to the establishment of the federal Compassionate Investigational New Drug program which ran from 1978 until 1992.

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